The Bowden Laboratory is equipped with several state-of-the art instruments, including a Thermo TSQ Quantis triple quadrupole mass spectrometer and a Thermo Q-Exactive quadrupole-orbitrap hybrid mass spectrometer. Both instruments are coupled to Thermo Vanquish ultra-high performance liquid chromatography systems and are equipped with an electrospray ionization source. In addition, ....
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The Thermo TSQ Quantis triple quadrupole mass spectrometer is ideal for targeted analyses of known compounds (e.g., personal-care products, pharmaceuticals environmental pollutants, hormones). This triple-quadrupole mass spectrometer offers very high sensitivity and robustness, with some of our methods having limits of detection in the low parts per trillion. Most studies performed using this instrument are hypothesis testing, using selected reaction monitoring scan mode to identify components in the sample. We are currently coupling 96-well plate technology to our current targeted assays.
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Typically used in discovery studies (hypothesis driving experiments), the Thermo Q-Exactive quadrupole-orbitrap hybrid mass spectrometer is capable of high-resolution analyses (up to 140,000 at m/z 200), sub-ppm mass accuracy with lock-mass correction and MS/MS with higher-energy collision-induced dissociation. This instrument is currently used in -omic studies, specifically lipidomics and metabolomics for pathway elucidation and the discovery of novel compounds as markers of disease, environmental exposure, and diet. We are also developing methods for the nontargeted analysis of per- and polyfluoroalkyl substances and chemicals of emerging concern in the environment.
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GC
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Extreva
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